Florida

Jonathan Singer at MyDD drops this demographic trend into the pot:

By the time of the next census, Florida may have as many congressional seats as New York. This prospect indicates that the Democrats need to get straight to work at strengthening the party infrastructure in the state so that Republicans are not able to indefinitely capitalize on the population shift away from so-called "blue states" to the so-called "red states."

I agree, and I'd take it farther.  The Democrats need work doubly hard in all southern and western states where the population is expanding.